Molecular basis of bacterial outer membrane permeability
نویسندگان
چکیده
منابع مشابه
Molecular basis of bacterial outer membrane permeability.
INTRODUCTION Bacteria produce cell walls with the exception of mycoplasmas, and the cell wall component common to all eubacteria is the murein, or the peptidoglycan, which contributes mechanical rigidity. All gram-negative bacteria contain an additional layer in the cell wall structure, i.e., the outer membrane, which is located outside the peptidoglycan layer and shows up as a trilaminar struc...
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Gram-negative bacteria characteristically are surrounded by an additional membrane layer, the outer membrane. Although outer membrane components often play important roles in the interaction of symbiotic or pathogenic bacteria with their host organisms, the major role of this membrane must usually be to serve as a permeability barrier to prevent the entry of noxious compounds and at the same ti...
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INTRODucnON ... ......... ........... .. . .. ........ ... ........ . .. .. ... .. ... . ......... .. ........ . 238 Structure oj the Cell Envelope.................................................................. 238 Uptake Arross the Outer Membrane.......................................................... 239 Intrinsic,Dejects in Outer Membrane Permeability in So.me Bacteria . .... ..... .. ....
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It is now well recognized that the outer membranes of gram-negative bacteria serve as molecular sieves which permit the passage of small hydrophilic molecules of sizes below a given cutoff, i.e., the exclusion limit (21, 27). This sieving property, which permits uptake of small substrate molecules but excludes potentially harmful enzymes and other large hydrophilic molecules, is due to a class ...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1985
ISSN: 0146-0749
DOI: 10.1128/mr.49.1.1-32.1985